Health information exchange (HIE) holds the potential to radically transform care by ensuring that accurate and up-to-date information is available to providers at the point of care. However, for reasons of expense, culture, or competition, some healthcare providers have been reluctant to integrate or adopt health IT systems capable of robust electronic data exchange. This paper describes the characteristics of successful enterprise HIE implementations and presents ten reasons why providers should participate in data exchange. Sponsored by RelayHealth.