The National Academies of Sciences, Engineering, and Medicine convened a workshop to assist the Federal Bureau of Investigation Weapons of Mass Destruction Directorate in understanding the applications and potential security implications of emerging technologies at the interface of the life sciences and information sciences. At the workshop, participants from wide ranging backgrounds discussed the rapid pace of growth in the bioeconomy, with a particular focus on the bioinformatics economy, and the imperative to safeguard it in the interest of national security.