Cybercrime has become an increasing concern for consumers in the United States and internationally. In recent years, cybercrimes in the healthcare industry have drastically increased in type, impact, and frequency. These attacks have negatively impacted patient privacy, the ability of providers to deliver care, and the security of healthcare organizations. Nurses are uniquely positioned to help protect against and report cybercrimes because they are one of the largest employed populations in the healthcare industry and they are on the front line of patient care and healthcare technology use. This article discusses the main concerns of cybersecurity in healthcare, the nurse’s role in preventing and managing cyber security, and recommendations for nurses, educators, and regulators.