Consider how artificial intelligence, machine learning, advanced data analytics, 5G networks, the internet of things, automation, cloud computing, and zero-trust cybersecurity are steadily transforming virtually every sector, including federal healthcare organizations. We see remarkable advancements unfolding almost daily in telehealth, genomics, precision medicine, wearable technologies and digital twins — to name just a few arenas of progress — that are rapidly changing the world of medicine and healthcare.